Article: Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Park YY; Johnston D; Gray R J. Neurophysiol., 2013
INaS, Activation | INaT, Activation | INaT, Inactivation | ||||||||||
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n | GNaS, max change, % | ΔV1/2, mV | Δk | n | GNaT, max change, % | ΔV1/2, mV | Δk | n | INaT, max change, % | ΔV1/2, mV | Δk | |
Hexanol | 18 | -71.1 ± 3.2‡ | -3.01 ± 0.70 | -0.45 ± 0.35 | 5 | -35.3 ± 8.0* | 2.05 ± 1.01 | 0.19 ± 0.14 | 4 | -23.3 ± 4.1* | -6.10 ± 1.03 | -0.16 ± 0.33 |
Riluzole | 7 | -73.9 ± 3.4‡ | -4.48 ± 1.48 | 0.28 ± 0.83 | 5 | -32.8 ± 6.4* | 1.89 ± 0.73 | 0.41 ± 0.46 | 4 | -27.1 ± 3.3† | -13.1 ± 1.41* | -0.90 ± 0.22 |
Ranolazine | 12 | -34.9 ± 5.0 | 0.55 ± 0.70 | 0.88 ± 0.22 | 7 | -25.0 ± 1.5 | 1.84 ± 0.48 | 0.10 ± 0.25 | 7 | -14.2 ± 1.6 | -3.34 ± 0.47 | -0.52 ± 0.20 |
Saline | 11 | -21.4 ± 4.6 | -1.54 ± 0.60 | -0.10 ± 0.30 | 5 | -10.4 ± 2.3 | -0.55 ± 0.65 | 0.07 ± 0.49 | 5 | -2.20 ± 3.1 | -3.84 ± 0.34 | -0.62 ± 0.53 |
Values are means ± SE. The effect of each drug was compared with the saline condition. Maximum conductance Gmax (or current amplitude Imax) change was calculated by (Gmax,Drug - Gmax,Baseline)/Gmax,Baseline × 100; ΔV1/2 (or Δk) was calculated by V1/2, Drug - V1/2, Baseline (or kDrug - kBaseline). Kruskal-Wallis test and post hoc Dunn's test:
↵* P < 0.05;
↵† P < 0.01;
↵‡ P < 0.001.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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